The BIG Vitamin D Story is about a GIGANTIC global health problem. The problem affects most people at sometime in their lifetime. It usually affects people in a hidden and quiet way, until disease strikes. The BIG problem is called the “Global Pandemic of Vitamin D Deficiency” (VDD). It needs to be proclaimed, explained, understood and simple, safe, and easy solutions proposed. Then, action can be taken by individuals and governments to solve the BIG global Vitamin D problem. Studies estimate that at least one billion people worldwide have VDD, along with 70-80% of people in the U.S., in general. About $20 to $40 of over-thecounter or off-the-shelf Vitamin D3, per person, per year, is all it should cost to start to solve the BIG problem. Correcting VDD can help people live healthier, happier and longer, and save people time, money and pain. Research models already conclude that annual health care costs could be reduced by at least 5% to 15%. In the U.S. alone, that would mean $155 to $465 BILLION dollars saved on the BIG annual 3.1 TRILLION dollar “bill”.

Vitamin D plays a GIGANTIC role in human health. Vitamin D, has often been called the “Sunshine Vitamin” because our bodies can make lots of Vitamin D when the sun shines on the bare skin. The past few decades our bodies have been making less and less Vitamin D for a number of reasons. Most people are indoors or in cars most of the time. Most people have most of their skin covered when outdoors year round, so our bodies have been making less and less Vitamin D. Meal sized portions of modern foods do not contain enough Vitamin D, even when fortified, to keep most people healthy. So, we are ingesting less and less Vitamin D. The need for supplementation has increased dramatically over the past few decades and must be addressed as soon as possible, after more people and government officials learn the BIG value of Vitamin D. One way to address this BIG Global Pandemic is to raise the current RDA for Vitamin D to proper health helpful levels.

Vitamin D was once thought to be just a vitamin. It was thought to be needed primarily for the development of teeth and bones. It is now understood to be the only vitamin to act like a hormone and have hundreds of actions within the body. Published research, in recent years, confirms that Vitamin D plays critical roles in innate and adaptive immunity. There are receptors in nearly every cell in the human body which helps to explain the hundreds of positive Vitamin D actions discovered in recent years. Research now shows that over 200 human illnesses are associated with Vitamin D Deficiency (VDD). Too little Vitamin D in the body, and too many people too often get sick. Currently, 30 to 100 ng/ml is considered a normal range of a Vitamin D serum test result in the body. Most people are below 30 ng/ml. Research already shows 50 to 70 ng/ml may be more disease preventive. Even higher levels may be found to be better once the Vitamin D Recommended Daily Dietary Allowance (RDA) guidelines are revised to be where they should be, per already published research. Then, more research can be done using higher levels of easy to take, safe and effective Vitamin D.

www.PubMed.gov Treasure: This writing contains hundreds of citation quotes and paraphrases from the National Institutes of Medicine data base called PubMed. PubMed currently contains 27 Million searchable article publications by title, key words and/or author for public view. Usually a search yields an abstract, which is a short summary of a published health study or research article. Usually a shortcut to a full article is posted on the citation page. Some full articles allow free view access while others charge a fee.

In The BIG Vitamin D Story PubMed citations are noted in brackets. The brackets usually contain a citation date and citation PMID#. You can fact check the content of this book and read more about a topic by going to www.PubMed.gov and putting the PMID number in the search bar at the top of the main page.

You Too Can Become A Treasure Hunter: You can learn to find study conclusions even when lots of medical terminology surrounds them. You too can learn to read citations and then be able to search out your own interests by placing key words in the search bar. Just beware and understand that bias does exist in too many “peer reviewed articles.” Bias is admitted, in many health publications. So search for general consensus and main themes as you dig for Treasure. Push aside the dirt and minor disagreeable publication conclusions.

Vitamin D Deficiency (VDD) is a global pandemic. VDD is estimated to affect one billion people worldwide and 70-80% of people in the U.S., with a range of 5% to 99% dependent upon age, race, group, location, etc. VDD causes massive global pain, suffering and death. “Actions are urgently needed to protect the global population from the threats posed by Vitamin D deficiency.” [2017 PMID: 28768407] Many studies proclaim a GLOBAL PANDEMIC of Vitamin D Deficiency. It has been written about since before 2008. [see PMID: 28516265 + 28513755 + 25856222 + 25071593 + 24219374 + 23364265 + 23306192 + 23075936 + 21896873 + 21702395 + 20590017 + 18400738] The VDD Pandemic remains in part due to the reportedly outdated nutrition guidelines set by a government paid organization. The guidelines affect the health of most all people reliant on those guidelines.

Vitamin D serum blood tests are rarely performed and not usually part of a regular blood screening. Some studies show that only about 5% of veterans are tested and even fewer get treatment, although most veterans have VDD. Hospitals rarely test incoming patients pre-admission. Yet, hospital length of stay and survival has been shown to be related to in-hospital Vitamin D levels.

VDD D3 treatment supplementation improves and prolongs life: Vitamin D3 supplements reduce pain, reduce suffering and reduce early death. A 2016 study documented “the benefits of a real-world preventive health program to Health-Related Quality of Life (HRQOL)” It was “first to reveal that improvements in Vitamin D status parallel improvements in HRQOL among healthy community dwellers.” [2016 PMID: 26282006] Remember, correcting VDD can help people live healthier, happier and longer.

VDD D3 treatment supplementation is safe, easy and cost effective. A one year supply of over the counter Vitamin D3 only costs $20 to $30. Very few people have died from Vitamin D3 overdose in the past TEN years. Vitamin D3 supplementation is very safe compared to the estimated 250,000 that die from medical errors EVERY year. [2016 PMID: 27143499] “Medical errors rank behind heart disease and cancer as the third leading cause of death in the U.S.” [NPR.org and CDC] It is estimated that proper Vitamin D levels could reduce healthcare costs by 5% to 15%, or more, along with reducing deaths.

History of the BIG Vitamin D RDA Problem: After WWII, the Recommended Dietary Allowance (RDA) for Vitamin D was reportedly 200 IU/day. The purpose of the RDA is to estimate the amount of any form of nutrition needed, per day, to keep 97-98% of “all” people healthy. Specific organizations, and people, provide national advice on issues relating to biomedical science, medicine, and health. They serve as advisers to the nation to improve health. In 2010, the Vitamin D RDA nutrition guidelines were raised to be 400-600 IU/day generally and 800 IU/day for over age 70. In 2014, it was published at least twice that “A statistical error in the estimation of the recommended dietary allowance for Vitamin D” was made. The “correct analysis of the original data” determined that adults needed 8895 IU/day for 97.5% of them to be and stay healthy–not 400 to 600 IU/day. [2014 PMID: 25333201] Others confirmed the correction and reported that adults needed 6201 to 9122 IU/d to achieve their recommendations. [2015 PMID# 25763527] In 2017, “The Big Vitamin D Mistake” article was published and summarized the BIG health issue problems associated with the statistical error in a conclusion statement: “Actions are urgently needed to protect the global population from the threats posed by Vitamin D deficiency.” [2017 PMID: 28768407]

As of 11/1/17, the National Institutes of Health (NIH) web-site still posts the Vitamin D RDA as 400 to 600IU/day or 800IU/day for ages 70 and over). Could this be one BIG reason that 5% to 99%, depending upon the group, or an average of 70% to 80% of Americans have VDD, in the year 2017?

NIH (National Institutes of Health)  PubMed articles say the following about Vitamin D Deficiency (VDD):

Acne: 

A study found that “VDD was more frequent in patients with acne and blood serum 25(OH)D levels were inversely correlated with acne severity, especially in patients with inflammatory lesions.” [2016 PMID: 27560161]

Acute Respiratory Distress Syndrome (ARDS):

“VDD is common in people who develop ARDS. VDD appears to contribute to the development of ARDS, so approaches to correct VDD in patients at risk of ARDS should be developed.” [2015 PMID: 25903964]

Allergies: 

A study found “In children with asthma and allergic diseases, VDD correlates strongly with asthma, allergic rhinitis and wheezing.” [2016 PMID 27022267] Another study found “serum Vitamin D levels were lower in asthmatics than controls. VDD was higher among children with asthma, allergic rhinitis, atopic dermatitis, acute urticaria and food allergy.” [2011 PMID: 21789969]

Alzheimer’s and Dementia: 

“In recent years, the associations between Vitamin D status and Alzheimer’s disease (AD) and Dementia have gained increasing interests.” Studies found that VDD increases the risks of developing both illnesses. “Lower Vitamin D status may be associated with increased risk of developing AD and Dementia.” [2015 PMID: 26231781]

Asthma: 

“There is growing literature suggesting a link between Vitamin D deficiency and asthma in children.” This study found “asthmatic children had lower 25(OH)D levels as compared to non-asthmatic children.” [2017 PMID: 28671167]

Atrial Fibrillation (AF): 

“Low plasma Vitamin D concentration was strongly associated with AF in patients with Chronic Heart Failure.” [2016 PMID: 26935498] A 2014 study “revealed a relationship between VDD and non-valvular AF” [2014 PMID: 22826443] A 2016 meta-analysis found that “VDD modestly increased the risk of AF” and called on more studies to determine how and whether Vitamin D supplements could prevent AF. [2016 PMID: 27556176]

Bald Spot Sudden Hair Loss: 

“Alopecia areata (AA) is an autoimmune disease.” This study “found a significant correlation between AA and VDD.” VDD can be a significant risk factor for alopecia areata occurrence. [2014 PMID: 25058999]

Breast Cancer (BC): 

In 2011, a published study found VDD was more common in women with breast cancer. [PMID: 21384167] In 2011, published results of case -controlled studies on the risk of breast cancer found that a serum level of 47 ng/ml was associated with a 50% lower risk of breast cancer. [PMID: 21868542] In 2012, a published study found VDD in 95.6% of BC patients vs. 77% of controls. Conclusion: “Invariably almost all patients with breast cancer were Vitamin D deficient.” [PMID: 22629509] In 2013, a published review of the literature said, “An increased 25-OH-D level seems associated with a decreased risk of breast cancer recurrence.” [PMID: 23562418] In 2014, a published study stated that VDD was found in 99% of breast cancer females.” Conclusion: Vitamin D deficiency was highly prevalent, beyond “normal” among breast cancer females.” [PMID: 25603674] In 2014, published results of a comprehensive search of several electronic databases “found that an increased serum level of Vitamin D is associated with decreased risk of breast cancer.” It was concluded that “Vitamin D plays a significant role in protection of breast cancer.” [PMID: 25560331] In 2017, a published study stated it found statistically significantly increased risk of breast cancer with low Vitamin D concentration.” Conclusion: This study “concluded that Vitamin D deficiency is associated with risk of breast cancer. The study considered VDD to be a serum level less than 20 ng/ml. [PMID: 28811787]

Cancer Patient Pain and Infections: 

A 2017 matched case-control study found that Vitamin D supplements given to palliative cancer patients “is safe and improves pain management as early as 1 month after treatment. Decreased infections are noted 3 months after Vitamin D treatment.” [2017 PMID: 28859173]

Carpal Tunnel Syndrome (CTS): 

CTS may be triggered by Vitamin D deficiency and severity correlates with the Vitamin D deficiency levels. [2016 PMID: 27062466] CTS pain intensity is increased by Vitamin D deficiency [2017 PMID: 28552837]

Cerebral Aneurysm: 

“Patients with cerebral aneurysms requiring treatment have a significantly higher incidence of hypo-Vitaminosis D (VDD) compared with patients in a control group.” [2016 PMID: 26748168]

Chronic Leg Ulcers: 

VDD was found to be more prevalent in patients with chronic venous leg ulcers than in a control group. [2012 PMID: 22481708]

Chronic Low Back Pain (LBP): 

“LBP is an extremely common problem in practice, where it is often labeled idiopathic.” People with LBP have significantly low VDD. [2007 PMID: 17377737] “VDD is a major contributor to chronic LBP in areas where VDD is endemic. Screening for VDD and treatment with supplements should be mandatory in this setting.” [2003 PMID: 12544936]

Chronic Obstructive Pulmonary Disease (COPD): 

VDD serum levels were found to be “inversely associated with COPD risk, severity, and exacerbation and associated with increased risk of COPD and severe COPD.” [2016 PMID: 27799758]

Chronic Pain: 

Chronic pain is very common in all types of patients that are keeping Emergency Rooms busy. Studies show that VDD caused muscle pain (myalgias) can have a profound and negative impact on an individual’s lifestyle.” Vitamin D supplement treatment can substantially improve the pain and also quality of life, after treatment. [2014 PMID: 24725820]

Chronic Urticaria (CU): 

CU is a common skin condition mostly of unknown cause. So symptom control therapy mainly uses antihistamines. But, CU symptoms improve with high Vitamin D3 supplementation. [2014 PMID: 25155458] “High dose Vitamin D3 (4,000 IU/d) could be considered a safe a potentially beneficial immuno-modulator in patients with chronic urticaria.” [2014 PMID: 24507460] “Replacement of Vitamin D may provide improvement in both the severity of symptoms and the quality of life scores in CU patients.” [2016 PMID: 26295454]

Chronic Musculo-Skeletal Pain: 

In forty-nine patients, VDD was severe and “correction resulted in a significant decrease in the level of pain intensity, consumption of analgesic and discomfort in activities of daily living.” VDD correction impacted physical, mental and social activities in a positive way. Correcting VDD is “a necessity before performing complex and expensive examinations.” [2013 PMID: 23332894]

Chronic Musculo-Skeletal Pain in Children: 

In pediatric populations the prevalence of VDD is high. In children, Vitamin D therapy possibly reduces pain intensity and improves mobility and daily function with mascula-skeletal/orthopedic disorders, chronic recurrent pain and VDD.”[2016 PMID: 26936061]

Chronic Widespread Musculo-Skeletal Pain (CWP): 

“Patients with CWP should be investigated for VDD. Vitamin D replacement treatment in patients with nonspecific CWP provided improvements in musculo-skeletal symptoms, level of depression and quality of life of patients.” VDD increases CWP and depression. [2016 PMID: 27860257]

Chronic Widespread Pain (CWP): 

“Including FM is a global musculo-skeletal disorder leading to disability and reduced quality of life.” A study found a positive crude association between VDD and CWP. [2015 PMID: 26431141]

Cognitive Impairment: 

VDD was “significantly associated with onset of Major Depressive Episode (MDE) and depression severity. has been associated with Low D and “Patients with MDE and VDD may be more prone to cognitive impairment. [2017 PMID: 28843080]

Colorectal Cancer (CRC): 

VDD is highly prevalent in CRC patients and a strong independent poor prognosis predictor. “Those in the lowest 25(OH)D3 quintile (<11.83 nmol/L) had a strongly increased mortality.” [2017 PMID: 28884317]

Critically Ill Surgical Patients: 

VDD “Vitamin D levels , 20 ng/ml have a significant impact on length of stay, organ dysfunction and infection rates.” More studies are needed on Vitamin D supplementation. [2012 PMID: 22206852]

Dementia and Alzheimer’s Disease: 

“In recent years, the associations between Vitamin D status and Alzheimer’s disease (AD) and Dementia have gained increasing interests.” Studies found that VDD increases the risks of developing both illnesses. “Lower Vitamin D status may be associated with increased risk of developing AD and Dementia.” [2015 PMID: 26231781]

Dental Disease: 

VDD is associated with gingivitis, periodontitis, early childhood dental cavities and tooth loss. [2014 PMID: 24828383 + 2017 PMID:28516265] “Vitamin D may reduce gingival inflammation– gingivitis–through its anti-inflammatory effects.” [2005 PMID: 16155270] “VDD has been associated with periodontitis and Vitamin D status may be critical for periodontitis post-surgical healing.” [2011 PMID: 21555774] “Higher maternal Vitamin D intake during pregnancy may be associated with a lower risk of dental caries in children.’ [2015 PMID: 25956333] “Maternal prenatal Vitamin D levels may have an influence on the primary dentition and development of Early Childhood Caries” in infants. [2014 PMID: 24753535] “Children with Severe Early Childhood Caries (S-ECC) routinely require dental surgery.” A pilot study pilot study found that children with severe early childhood caries had lower Vitamin D levels than age-matched controls.[2012 PMID: 22811377] A case-control study found that “Children with severe early childhood caries have relatively poor nutritional health and were significantly more likely to have VDD.” [2013 PMID: 24160554]

Depression and Suicide: 

“Cross-sectional studies show an association between Vitamin D deficiency and depression, schizophrenia and psychotico-skeletal symptoms. Suicide attempters had significantly lower mean levels of Vitamin D than depressed non-suicidal patients and healthy controls.” Routine clinical VDD testing could benefit patients with suicidal symptoms, if Vitamin D supplements were prescribed in patients found to have VDD. [2014 PMID: 25240206]

Eczema: 

One study found VDD was inversely associated with eczema in children and adolescents. [2013 PMID: 23751100]

Epilepsy: 

“Several studies have shown a link between VDD and epilepsy” and VDD levels were found to be significantly lower in epileptics than in a control group. [2015 PMID:25637647] “Epilepsy is the most common serious neurological condition and sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death.” “Studies have shown a link between VDD and epilepsy.” Some SUDEP cases can be related to low VDD. [2010 PMID: 19666211]

Exclusively Breast-fed Infants: 

A 2006 published study found that about 26% of exclusively breast fed infants with hypo-calcemic seizures had VDD. The study emphasized “the need to supplement Vitamin D in exclusively breast fed infants and also to encourage exposure to sunlight in them and their mothers.” [2006 PMID: 16585820]

Fibromyalgia (FM): 

“FM is a chronic syndrome with an increasing prevalence, characterized by widespread musculo-skeletal pain in combination with a variety of cognitive symptoms and fatigue.” VDD is highly prevalent in patients with FM. [2016 PMID: 27271665]

Hair Loss and Thinning: 

VDD and iron and zinc deficiencies are significant with Telogen Effluvium (TE). TE is one of the most common forms of non-scarring hair loss and is a challenging disorder to treat and study. [2016 PMID: 27741341]

Headaches and Body Pain in Children: 

Chronic tension type “headache, musculo-skeletal pain and VDD are common in the general population and likely related.” Headaches and musculo-skeletal pain responded markedly to Vitamin D therapy.” When seen together in a patient VDD may be the cause of a symptom complex. [2016 PMID: 26838301]

Headaches and Osteomalacia: 

This 2009 publication was about 8 patients with chronic tension-type headache and VDD osteomalacia who “all responded poorly to conventional therapy for tension headache.” “The headache and osteomalacia of each of the 8 patients responded to Vitamin D and calcium supplementation.” Headaches improved much sooner than the osteomalacia.” [2009 PMID: 19619241]

Hip Fractures: 

A 2013 published study of acute hip fractures in a sunny climate found, “The majority of patients aged 18 years or older of both sexes with hip fracture were found to have Vitamin D insufficiency. And those aged 71 years or older had significantly lower 25(OH)D levels than a control group of total joint patients.” [2013 PMID 23515125]

Hospital Pre-Admission Vitamin D Levels: 

“VDD before hospital admission is a significant predictor of short-and long-term all-cause patient mortality and blood culture positivity in critically ill patients.” [2011 PMID: 21242800] VDD “prior to hospital admission is a significant predictor of sepsis in the critically ill. Additionally, patients with sepsis and VDD have increased risk of mortality (death) following critical care initiation.” [2014 PMID: 23982028]

Intensive Care Unit (ICU) Mortality: 

A 2011 study found “association between VDD and hospital mortality (death) in Medical ICU patients.” It called for a study on how Vitamin D supplements affect mortality. [2011 PMID: 22152332] VDD is “rarely considered and rarely treated with replacement, if at all, in critically ill patients in intensive care (ICU).” And VDD “may be an unrecognized contributor to adverse outcome in ICU patients.” [2009 PMID: 19756497] A 2014 meta-analysis suggested “that VDD increases susceptibility for severe infections, sepsis, and mortality in the critically ill.” [2014 PMID: 25475621] A 2015 study suggests that “low Vitamin D levels on ICU admission are an independent risk factor for mortality in critically ill patients.” [2015 PMID: 26039948]

Intensive Care Unit (ICU) Survival: 

A 2012 analysis found that the “length of stay, surgical intensive care unit cost and mortality (subject to death) was significantly associated with VDD.” [2012 PMID: 22325335] A 2012 “study demonstrated that low Vitamin D levels are common in patients admitted to the ICU . It found longer survival times in patients sufficient in Vitamin D. It concluded that “Vitamin D concentration may be either a bio-marker of survival or a co-factor.” [2012 PMID: 22331959] A 2012 study found that Vitamin D status decreased significantly over the duration of a patient’s ICU stay. It also found low levels of Vitamin D “associated with longer time to ICU discharge alive and a trend toward increase risk of ICU-acquired infection.” [2101 PMID: 22523178] “Serum Vitamin D levels within 24 hours of ICU admission may identify patients at high risk for prolonged hospitalization, readmission, and mortality.” [2014 PMID: 24557421] “VDD is a potentially modifiable marker for adverse outcomes in critical illness and critical illness trials. Vitamin D supplementation is inexpensive and appears safe in critical illness trials.” More research is needed to determine the role of Vitamin D supplements in improvement of critical care outcomes. [2015 PMID: 25635597]

Intensive Care Unit (ICU) Survival of Veterans: 

ICU outcomes in veterans are affected by VDD. Correcting VDD may “reduce costs and confer survival advantages in critical illness.” Vitamin D levels should be routinely checked and deficiencies treated in ICU Veteran patients. [2011 PMID: 21333923]

Irritable Bowel Syndrome (IBS) in Children: 

In this study “pediatric patients with IBS had significantly lower 25(OH)D concentration compared to controls.” While 7% of the children and adolescents with IBS were Vitamin D sufficient, over 50% had VDD at a higher rate than in other mal-absorption syndromes. [2017 PMID: 28192499]

Melanoma Cancer: 

“Evidence shows that people with thicker, or higher stage, melanomas have lower Vitamin D status compared to thinner tumours.” VDD at the time of diagnosis is associated with thicker tumors that are likely to have poorer prognosis.” Ensuring higher Vitamin D levels could result in some thinner melanomas with better prognosis. [2015 PMID: 25970336]

Metabolic Syndrome: 

VDD may increase the risk of developing metabolic syndrome, per several studies. Researchers also found “a statistical significant inverse relationship of increases in serum 25(OH)D with risk for metabolic syndrome.” “Improvement of Vitamin D status may help reduce the public health burden and potential subsequent health conditions including type 2 diabetes and cardiovascular disease.” [2015 PMID: 26343719]

Migraine Headache Pain: 

Study “findings may suggest that decreased serum Vitamin D levels (VDD) were associated with migraine.” [2014 PMID: 24837712]

Migraine and Tension Type Headache: 

This study noted a “significant relation between prevalence of both tension-type headache and migraine with latitude” suggesting a role of VDD in the generation of head pain. [2010 PMID: 20464624]

Multiple Sclerosis (MS): 

VDD is one of the risk factors for MS, especially at the early stages of MS. Different types of studies have implicated VDD in MS. Vitamin D plays a significant role in the immune system and is now known to influence T-cells that play a role in MS disease. VDD in MS patients is seen in a great majority of patients. [2010 PMID: 20584945]

Osteomalacia and Headaches: 

This 2009 publication was about 8 patients with chronic tension-type headache and VDD osteomalacia who “all responded poorly to conventional therapy for tension headache.” “The headache and osteomalacia of each of the 8 patients responded to Vitamin D and calcium supplementation.” Headaches improved much sooner than the osteomalacia.” [2009 PMID: 19619241]

Postpartum Depression (PPD): 

“PPD is a common emotional disorder which negatively affects women, infants and family.” Abnormal levels of Vitamin D have been associated with depression in the postpartum population. [2016 PMID: 27807334]

Premenstrual Syndrome-Related Mood Disorders in Adolescents: 

“Vitamin D therapy can be proposed as a safe, effective and convenient method for improving the quality of life in young women with severe hypoVitaminosis D (VDD) and concomitant mood disorders associated with PMS.” [2016 PMID: 26724745]

Prostate Cancer: 

“VDD was associated with increased odds of prostate cancer diagnosis on biopsy and severe deficiency was positively associated with higher Gleason grade and tumor stage.” [2014 PMID: 24789033]

Psoriasis: 

“Oral Vitamin D is inexpensive, easily available and effective as a treatment for psoriasis.” [2013 PMID: 22103655]

Schizophrenia:

Schizophrenia may be the most severe psychiatric disorder and cause remains a puzzle. [2012 PMID: 22646662] “VDD has been linked with schizophrenia. Average Vitamin D values were deficient for first episode patients, especially those with a final diagnosis of schizophrenia.” [2017 PMID: 28406840] “Regular screening for Vitamin D status of patients with schizophrenia is suggested in order to allow for the institution of appropriate clinical intervention when necessary.” [2017 PMID: 28659835]

Spinal Fusion: 

“Vitamin D plays a critical role in establishing optimal bone health, which is vital to spinal arthrodesis” (fusion of vertebrae). A retrospective study “found a substantially high prevalence of Vitamin D abnormality in the population studied” that required spinal fusion. It stated that “spinal disability indices may be useful in identifying those with VDD. It further stated, that young adults with spinal disabilities were in an age bracket where Vitamin D screening was often overlooked and should not be, because they are less likely to take D supplements prior to surgery and likely to have VDD pre-surgery. [2013 PMID: 22986835]

Suicide and Depression: 

“Suicide attempters had significantly lower mean levels of Vitamin D than depressed non-suicidal patients and healthy controls. Cross-sectional studies show an association between Vitamin D deficiency and depression, schizophrenia and psychotico-skeletal symptoms.” Routine clinical VDD testing could benefit patients with suicidal symptoms, if Vitamin D supplements were prescribed in patients found to have VDD. [2014 PMID: 25240206]

Warts: 

Vitamin D3 is effective in treating senile warts and do so without pain. “Tumors faded without inflammatory changes such as erythema or swelling.” Vitamin D3 may affect senile warts by inducing cell apoptosis (cell death) Vitamin D3 ointments are widely used to treat skin disorders like psoriasis. “Clearance of senile warts, especially on exposed areas without pain, may improve the quality of life of the elderly.” [2005 PMID: 16043912]

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